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In this phase II trial involving 50 men with metastatic castration-resistant prostate cancer (mCRPC), the administration of docetaxel combined with oral curcumin (6 g/day for 7 days every 3 weeks) demonstrated no significant differences in progression-free survival (PFS), PSA response, overall survival, or quality of life (QoL) when compared with placebo, despite high compliance and confirmed curcumin absorption

doi: 10.1016/j.biopha.2019.108612

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SNO of this protein leads to its phosphorylation at Ser616, and thus, activation of fission in hippocampal neurons [318]

) 30 min before the Y-maze test

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